Damian Lillard had 13 points and 12 assists as Portland snapped a four-game losing streak.
Anthony was 10 for 20 from the field, including 4 of 7 on 3-pointers. He now has 25,615 career points to move ahead of Alex English (26,613) into 18th place on the NBA’s career scoring list.
Zach LaVine had 18 points for Chicago, which has dropped two of three. LaVine was just 1 for 5 on 3-pointers two days after making 13 of 17 while scoring a career-high 49 points Saturday at Charlotte.
Anthony, who signed with the Trail Blazers on Nov. 19, got off to a fast start with 12 points in the first 6½ minutes of the game.
Chicago led 28-27 at the end of the first quarter before Portland took command early in the second. The Blazers led by as 13 points before the Bulls scored 11 straight to pull within 50-48.
Portland closed the first half with a 12-6 spurt for a 62-54 halftime advantage.
The Trail Blazers further stretched the lead in the third, taking a 90-68 advantage — their biggest to that point — on Anthony’s three-point play with 1:27 to go in the quarter.
Early in the fourth, Anthony hit a 3-pointer to move past English and give Portland a 100-77 lead.
The 35-year-old exited the game for good shortly after that. The United Center crowd started chanting “We want Melo! We want Melo!” midway through the fourth.
The Trail Blazers led by as much as 28 points.